It all depends on the size of the CO2 reactor. You would have to find an adapter (we do not sell them) to attach the air intake hose to the reactor. Please know that when you reduce the intake of air into the skimmer, it will affect the performance of the skimmer and may need to be tweaked and retuned. It may also render the skimmer inoperable if the air intake is obstructed to the point where the skimmer cannot pull sufficient air for it to work.